One type of PDE inhibitor is Tadalista Professional. It treats erectile dysfunction by relaxing the muscles in the penile blood arteries, which increases blood flow to the penis. Follow your doctor's instructions on the dosage and duration of this medication. Take it all in at once. Never shatter, eat, or crush it. When combined with alcohol, it may result in low blood pressure and dizziness. Before beginning to use tadalafil and each time you receive a refill, read the Patient Information Leaflet, if it is available from your pharmacist. Take this drug orally, as prescribed by your physician, either with or without food. Tadalafil should not be taken more than once per day.